Gene information
Official symbol CDKN2B
Official full name cyclin dependent kinase inhibitor 2B
Gene type protein-coding gene
Chromosome9p21.3
Alias symbolP15; MTS2; INK4B; TP15; CDK4I; p15INK4b
Resources
Entrez Gene 1030
HGNC HGNC:1788
Ensembl ENSG00000147883
Vega OTTHUMG00000019691
UCSC uc003zpo.4
GO terms: 69 records
GO Description Category LogP Number of genes Detail
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO Biological Processes -2.86415470 5 More
GO:0001889 liver development GO Biological Processes -10.3922429 25 More
GO:0001933 negative regulation of protein phosphorylation GO Biological Processes -19.8214973 59 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0004860 protein kinase inhibitor activity GO Molecular Functions -1.86227148 3 More
GO:0006469 negative regulation of protein kinase activity GO Biological Processes -12.6852914 37 More
GO:0007346 regulation of mitotic cell cycle GO Biological Processes -10.6017433 22 More
GO:0007584 response to nutrient GO Biological Processes -29.4823239 48 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010564 regulation of cell cycle process GO Biological Processes -6.45429517 20 More
GO:0010948 negative regulation of cell cycle process GO Biological Processes -6.78057192 13 More
GO:0014013 regulation of gliogenesis GO Biological Processes -13.3514185 26 More
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway GO Biological Processes -7.26381098 23 More
GO:0019210 kinase inhibitor activity GO Molecular Functions -2.42307363 9 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0019901 protein kinase binding GO Molecular Functions -6.66055444 59 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway GO Biological Processes -4.06072292 4 More
GO:0030856 regulation of epithelial cell differentiation GO Biological Processes -15.4645914 35 More
GO:0030858 positive regulation of epithelial cell differentiation GO Biological Processes -9.94639997 18 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0031668 cellular response to extracellular stimulus GO Biological Processes -10.2327580 36 More
GO:0031669 cellular response to nutrient levels GO Biological Processes -9.42886914 32 More
GO:0031670 cellular response to nutrient GO Biological Processes -9.31154255 13 More
GO:0033673 negative regulation of kinase activity GO Biological Processes -12.5521161 39 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO Biological Processes -4.06072292 4 More
GO:0045786 negative regulation of cell cycle GO Biological Processes -11.4279863 20 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045930 negative regulation of mitotic cell cycle GO Biological Processes -12.1211141 17 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050680 negative regulation of epithelial cell proliferation GO Biological Processes -26.5961536 48 More
GO:0050767 regulation of neurogenesis GO Biological Processes -15.7439029 55 More
GO:0051348 negative regulation of transferase activity GO Biological Processes -13.2006110 43 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0061008 hepaticobiliary system development GO Biological Processes -10.9353398 26 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071496 cellular response to external stimulus GO Biological Processes -17.0078490 52 More
GO:0071559 response to transforming growth factor beta GO Biological Processes -17.0634996 37 More
GO:0071560 cellular response to transforming growth factor beta stimulus GO Biological Processes -16.8909657 36 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071901 negative regulation of protein serine/threonine kinase activity GO Biological Processes -13.7044922 29 More
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -13.1150464 44 More
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO Biological Processes -10.5573443 25 More
GO:0090287 regulation of cellular response to growth factor stimulus GO Biological Processes -21.1381780 60 More
GO:0090398 cellular senescence GO Biological Processes -3.46605627 5 More
GO:1901987 regulation of cell cycle phase transition GO Biological Processes -7.48321149 17 More
GO:1901988 negative regulation of cell cycle phase transition GO Biological Processes -6.79968458 12 More
GO:1901990 regulation of mitotic cell cycle phase transition GO Biological Processes -9.06841215 17 More
GO:1901991 negative regulation of mitotic cell cycle phase transition GO Biological Processes -8.19381421 12 More
GO:1902806 regulation of cell cycle G1/S phase transition GO Biological Processes -9.32363308 14 More
GO:1902807 negative regulation of cell cycle G1/S phase transition GO Biological Processes -8.70120563 10 More
GO:1903844 regulation of cellular response to transforming growth factor beta stimulus GO Biological Processes -8.41113232 25 More
GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus GO Biological Processes -4.06072292 4 More
GO:1904029 regulation of cyclin-dependent protein kinase activity GO Biological Processes -2.81419448 5 More
GO:1904030 negative regulation of cyclin-dependent protein kinase activity GO Biological Processes -4.06072292 4 More
GO:2000045 regulation of G1/S transition of mitotic cell cycle GO Biological Processes -10.1341432 14 More
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle GO Biological Processes -9.22212459 10 More
KEGG pathways: 7 records
KEGG Description Category LogP Number of genes Detail
hsa04068 FoxO signaling pathway KEGG Pathway -6.87449445 21 More
hsa04350 TGF-beta signaling pathway KEGG Pathway -6.45304971 17 More
hsa04934 Cushing syndrome KEGG Pathway -3.26102406 8 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05203 Viral carcinogenesis KEGG Pathway -1.94955729 7 More
hsa05222 Small cell lung cancer KEGG Pathway -6.83164026 10 More
hsa05226 Gastric cancer KEGG Pathway -5.33653529 20 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
palbociclib CIViC 23898052 view
Related studies: 3 records
Molecular factor Omics type Application Objective MI type Reference
CDKN2B transcriptomics myocardial infarction[diagnosis] myocardial infarction Zivotic I et al. Clin Biochem. 2019
NC_000009.12:g.22003368G>A genomics myocardial infarction[diagnosis] myocardial infarction Yang XC et al. Clin Biochem. 2009
NM_004936.4:c.*656A>C genomics myocardial infarction[diagnosis] myocardial infarction Helgeland O et al. Int J Endocrinol. 2015
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